Recent content by evilbooyaa

Is it a huge ITV? Or is it just like a regular ITV?

Posts related to RTOG 0848 and PEACE-1 have been moved to their own respective threads

I was not aware that it had a true RT randomization. All I had heard about the trial was the benefits but potential toxicities of adding Abi to ADT + Docetaxel (triple therapy), and the fact that RT maybe helped reduce major GU events (but one of the 'major GU events' was receipt of RT, so does...

Don't forget reducing risk of pancreatic leak/fistula with pre-op RT: https://www.surgjournal.com/article/S0039-6060%2824%2900055-2/fulltext

Unfortunate. For some people the kool-aid blinds them to what's actually happening to the patient in front of them. If somebody got prostate SBRT and then recurred 6 months later, I wouldn't be recommending additional radiation to them. Because patterns of failure analyses suggest opposite of...

Sure it was a med onc and not a med onc NP/PA? Algorithms can be hard to shake sometimes.

Agreed - we ignore benefits of fractionation in a desire to shorten everything to 5 treatments. Would love to see 15-25Fx with SIB make its way into a cooperative group trial (even if it was just an option that was say stratified for) Probably not more nodal failures than more chemo (unless tox...

No elective nodal coverage mandated in the protocol. Trial will be negative with significant nodal/marginal failures in the SBRT arm. Only one of two lessons learned from the ALLIANCE trial which they do cite in their protocol.

I have not done a deep dive on PEACE-1 previously, but read through the website you linked. Median f/u of 6-years to assume that OS would be benefited by 32% (goal HR of 0.68) in the experimental arms (in the MAIN group, NOT this tiny subset analysis you are quoting)? Not a realistic goal...

Maybe the previous post was a bit harsh, but I feel like I'm seeing a trend that anything that supports radiation in any manner is immediately poo-poo'd. But seriously, if the trial is going to give us a result like this and we're not going to listen to it, while simultaneously ignoring, then...

What does PEACE-1 have to do with prostate RT? Oligomet M1 prostate cancer receiving ADT and Abi should 100% receive prostate RT until a trial proves it is unnecessary. Why assume benefits are NOT additive across two different modalities (local vs systemic) when there are active trials accruing...

I personally disagree. Continuing to move the goal posts when the trial took 16 years to just get a damn presentation is really useless. If we're going to ignore a positive trial (at least for pN0) why did we even run it???

In Table S3 of PRODIGE 24, locoregional alone (13.4) or LR + distant recurrence (9.7%) made up 23% of all the patients (as opposed to 28% having isolated distance recurrence), cumulative 54.2% DFS event Yes, those numbers are better than Gemcitabine - 18% LR alone, 17.1% LR+ distant, or 35% of...

I think proving safety and efficacy in ph I/II studies for pancreas SBRT to high doses (not 33/5) was definitely warranted given the negative experiences from early pancreas SBRT. And despite @OTN saying he's doing 50/5 regularly with CT based imaging, I wouldn't be able to feel confident in...