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Single arm ph II? The conclusion is that it is A SOC. That is a reasonable statement.View attachment 386290
So, 25 x 2.5 Gy = 62.5 Gy is well tolerable.
However, isn't there a "hidden" dose escalation when going for hypofractionation with this regime?
Isn't 25 x 2.5 Gy = 62.5 Gy "more dose" than 33 x 2 Gy = 66 Gy?
With ab a/b of 3 Gy, 24 x 2.5 Gy would be equivalent to 33 x 2 Gy (BED 110 Gy).
The tweeter stating that Hypo is THE SOC is excessive. Shouldn't be hard to do a ph III to prove it's just as safe compared to contemporary conventional fractionated.
Assuming A/b of prostate cancer is 3 in the recurrent setting.... that's a dangerous move!
Confirms my practice. To take a potentially curative situation of lymph node recurrence of prostate cancer and put the patient on a palliative pathway by not doing ENRT, does not compute.
3% vs 25% chance of recurrence. I know which one I'd want if I was a patient! Their toxicity data for ENRT vs MDRT was basically the same as well.
Nodal SBRT in someone who has not prevoiusly seen elective nodal RT is not the answer.
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