anyway one of patient's with nephrotic syndrome and primary hypoparathyroidism just got a renal biopsy back as primary membranous nephropathy PLA2R positive (I call this "plotter positive"). intriguing.
Kidney biopsy:-Diffuse membranous glomerulonephritis, stage 2-3, PLA2R positive.-Global glomerulsclerosis (3/30).-Rare foci of tubular atrophy.-Mild arterio- and arteriolosclerosis.-No segmental or global proliferative lesions noted.
here is some "beautiful" renal path images
diffuse glomerulosclerosis
look at that spike and domes!
look at that podocyte effacement!
now its time to update his age appropriate cancer screening and investigate his hypoparathyroidism a bit more deeply (as his PCP isn't following my reccs)
anyway this patient's insurance will cover calcitriol but not Tums go figure
This patient won't spend money on Tums so I've had to give calcium acetate (not indicated for his Ph of 5.5 I know and it has low elemental calcium compared to carbonate. but hey if hes not shelling out for Tums gotta do something)
anyway i find the rat inside this same patient's lungs far more interesting
addendum: this patient has nephrotic syndrome due to primary membranous nephropathy
he also ha tuberculosis 2 years ago treated. he has a cavity and now he has been diagnosed with chronic cavitary pulmonary aspergillosis
this might be hard to treat. doing okay on voriconazole at the moment
he is considered "moderate risk of progression" for his membranous so just doing ARB and dietary control at the moment
I'd hate to see what happens to his CCPA if I arranged rituximab (not in my office but a NY blood and cancer - third party infusion center) for him.
this kind of case really needs a multidisciplinary approach but this patient is.... not documented.... refuses to go into tertiary care center .... has managed Medicaid though (nice for this patient).... I am solo-ing this case. wish me luck.