When to initiate treatment in patients with HIV

A 60-year-old man who is HIV positive presents with fever, dyspnea, and inflammatory lesions on the skin. A biopsy reveals a diagnosis of histoplasmosis. At what threshold should antiretroviral therapy (ART) be initiated in adults with HIV?

A. Any CD4 count
B. A CD4 count less than 350 cells/mm³
C. A CD4 count less than 500 cells/mm³
D. A CD4 count less than 200 cells/mm³

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