If you answer this pharm question, you know your pharm well

[warriordoc911]

Xanthine oxidase is inhibited by:

1. Allopurinol
2. Xanthine
3. Alloxanthine
4.Hypoxanthine
5. Uric acid
6. I don't know and I better review my pharm notes

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[MilkmanAl]

So the quality of your pharm knowledge is contingent on whether you know an obscure metabolic pathway?

 

[winkleweizen]

7) dingle berries

 

[Day man]

7) dingle berries

Well that explains my low uric acid output! Hey-oh, nerd humor, lookout!

Studying 12 hours a day really makes your mind go haha.

 

[warriordoc911]

Is it obscure because you don't know it and it's not found in FA? well they have asked this kind of question before according to Kaplan professor and it's in kaplan pharm book too. This kind of question tests if the student just memorized the stuff or they understood. FYI since you don't know it, Allopurol is converted to Alloxanthine by Xanthine Oxidase and it's this product that inhibits Xanthine oxidase. Folks what's not found in FA doesnt mean it's not HY.

So the quality of your pharm knowledge is contingent on whether you know an obscure metabolic pathway?

 

[Mellow Monster]

Is it obscure because you don't know it and it's not found in FA? well they have asked this kind of question before according to Kaplan professor and it's in kaplan pharm book too. This kind of question tests if the student just memorized the stuff or they understood. FYI since you don't know it, Allopurol is converted to Alloxanthine by Xanthine Oxidase and it's this product that inhibits Xanthine oxidase. Folks what's not found in FA doesnt mean it's not HY.

it actually is in FA btw.

 

[Mr hawkings]

it actually is in FA btw.

Its in the biochem portion of my 2009 version.
OP, either its not in the current version or you didnt read it as well as you should

 

[Mellow Monster]

Its in the biochem portion of my 2009 version.
OP, either its not in the current version or you didnt read it as well as you should

haven't checked biochem portion, but it's in the section on gout drugs in FA 2011

 

[WellWornLad]

This would be among the easiest questions I'd expect on step 1. Not least of all because it takes all of 5 seconds to either answer it or realize you're screwed.

 

[mednsports]

Know my pharm????? I wish that was on my step (it wasn't).

 

[ar2388]

answer is allopruinol right? lol... thats what FA says..

 

[DrYoda]

Knowing that just means you passed biochem.

and allopurinol and alloxanthine both inhibit xanthine oxidase (allopurinol is converted by xanthine oxidase after-all ), it's just that alloxanthine has a longer half-life.

 

[UMP]

I had that question recycled twice through yesterday in my QBank, and for some reason it's been stuck in my head all day... and now you post it here... weird

 

[ShowStopper]

lol this is more of biochem than pharma.

 

[MilkmanAl]

This kind of question tests if the student just memorized the stuff or they understood.

Asking what enzyme a drug inhibits tests understanding? Yeah...

 

[Torquer]

Asking what enzyme a drug inhibits tests understanding? Yeah...

so i wasnt the only one wondering where the understanding was in memorizing the enzyme/drug interaction

 

[engineeredout]

If allopurinol has to be metabolized to alloxanthine, then isn't allopurinol itself still a competitive inhibitor of Xanthine oxidase because the enzyme is converting the allopurinol instead of hypoxanthine?

 

[BlondDoctor]

If allopurinol has to be metabolized to alloxanthine, then isn't allopurinol itself still a competitive inhibitor of Xanthine oxidase because the enzyme is converting the allopurinol instead of hypoxanthine?

Yes.

This whole thread is so random, I don't get it... I think it smells Trolly in here..