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Guero was born and raised in Los Angeles, educated in the South, and returned to the West for residency training. Self-identified as a genderqueer transwoman, she has remained dedicated to LGBTQ health policy, education, and activism, as well as basic science and clinical research throughout college, medical school, and residency. She is a firm believer in "paying it forward," sharing advice and resources in the pre-medical forums, serving on SDN's editorial board, co-creating and moderating the LGBTQ forum.