An interesting Oral Pathology subject?

[Beestieboy]

Hey there folks. I'm in a great Pathophysiology class right now and we will be doing a paper this semester about a human pathologic condition (one of our choice). Since I'm going to dental school next year I want to pick something to do with Oral Pathology. We just need to have a bunch of Peer-Reviewed sources so if that rings a bell with anyone, please share! I'm sure those of you further along in your dental education have seen some pretty nasty, but maybe interesting, stuff. What kind of oral nastiness would have peer-reviewed sources on it? Black hairy tounge? Meth mouth? (Nasty but I doubt I'll find many sources on that one) Something else? Thanks much.

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[TKD]

Hey there folks. I'm in a great Pathophysiology class right now and we will be doing a paper this semester about a human pathologic condition (one of our choice). Since I'm going to dental school next year I want to pick something to do with Oral Pathology. We just need to have a bunch of Peer-Reviewed sources so if that rings a bell with anyone, please share! I'm sure those of you further along in your dental education have seen some pretty nasty, but maybe interesting, stuff. What kind of oral nastiness would have peer-reviewed sources on it? Black hairy tounge? Meth mouth? (Nasty but I doubt I'll find many sources on that one) Something else? Thanks much.

Pick up the OOOOE journal (Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics), or Journal of Oral and Maxillofacial Surgery. These, and plenty of other peer-reviewed journals will have lots of interesting articles for you to choose from.

 

[Beestieboy]

Thanks! That will be a great place to get peer-reviewed journal stuff. Now, how about subjects? What's the craziest, or better yet, most interesting pathological (yes, oral) condition you've seen?

 

[Blue Tooth]

Well, the new big thing is bisphosphonate associated osteonecrosis of the jaws.

 

[Beestieboy]

Ohh, sounds like fun. Anything else anyone? Anyone?

 

[rarm1]

Hello
and congrats on your acceptance to dental school.

sounds like most of the topics you and the others suggested are in my fields or oral medicine/oral pathology/special care dentistry.

The bisphosphate osteonecrosis is recent in current literature... most in last 3 years... but goes back over 100 years with "phosy jaw" in match makers and a genetic syndrome OSTEOPETROSIS.. so it may cover multiple areas of pathophysliology.

Other "hot" topics is dental disease (infection/periodontal) and effects on pregnancy(low birth weights); heart disease (causing? vascular changes, causing endocarditis); aspiration pneumonia, etc

Others are in areas of salivary gland problems and dry mouth, caries, especially in geriatric patients, cancer patients.

You can email any time, or call for information... a literature search is easy with medlars,

Hosp # 302-428-6468
home # 302-752-0838
cell # 302-530-6788

email - [email protected]

(yes my students when I taught at Louisville and temple and my residents say I am crazy always being available... but i dont care)

 

[SuperC]

One more suggestion....
I did my undergrad research on molecular mechanisms of pathogenesis of Porphyromonas gingivalis (P. gingivalis), a bacterium that is associated with adult periodontitis and recently reported to be involved in cardiovascular disease.

There is a TON of work done in this area. Just search pubmed and you will be set.

Here are just a few citations from my work.


Ansai, T., E. Yamamoto, et al. (2002). "Effects of periodontopathic bacteria on the expression of endothelin-1 in gingival epithelial cells in adult periodontitis." Clin Sci (Lond) 103 Suppl 48: 327S-331S.
Awano, S., T. Ansai, et al. (1999). "Sequencing, expression and biochemical characterization of the Porphyromonas gingivalis pepO gene encoding a protein homologous to human endothelin-converting enzyme." FEBS Lett 460(1): 139-44.
Barker, N. and H. Clevers (2000). "Catenins, Wnt signaling and cancer." Bioessays 22(11): 961-5.
Barua, R. S., J. A. Ambrose, et al. (2002). "Heavy and light cigarette smokers have similar dysfunction of endothelial vasoregulatory activity: an in vivo and in vitro correlation." J Am Coll Cardiol 39(11): 1758-63.
Barua, R. S., J. A. Ambrose, et al. (2002). "Smoking is associated with altered endothelial-derived fibrinolytic and antithrombotic factors: an in vitro demonstration." Circulation 106(8): 905-8.
Beck, J., R. Garcia, et al. (1996). "Periodontal disease and cardiovascular disease." J Periodontol 67(10 Suppl): 1123-37.
Birchmeier, W. and J. Behrens (1994). "Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness." Biochim Biophys Acta 1198(1): 11-26.
Carroll, G. C. and R. J. Sebor (1980). "Dental flossing and its relationship to transient bacteremia." J Periodontol 51(12): 691-2.
Carson, J. A., T. Ansai, et al. (2002). "Characterization of PgPepO, a bacterial homologue of endothelin-converting enzyme-1." Clin Sci (Lond) 103 Suppl 48: 90S-93S.
Chen, C. S., M. Mrksich, et al. (1997). "Geometric control of cell life and death." Science 276(5317): 1425-8.
Chen, S., D. C. Guttridge, et al. (2001). "Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription." J Cell Biol 152(1): 87-96.

-C

 

[Beestieboy]

Just beautiful. Thank you so much guys. I think I probably will be calling you Dr. Arm. Thanks for being available!

 

[Doggie]

I think a very common thing you see in patients is various kinds of bony cysts. For dentists and even specialists, it's quite common to see these types:

- radicular cyst
- dentigerous cyst
- globullarmaxillary cyst
- nasolabial cyst