How to Write a Prescription (with Examples) | 7 Steps for Safety

Kunal Sindhu

Updated October 26, 2025 by Kunal Sindhu
Student Doctor Network Review: Volume 8, Issue 3, Article 1

How to write a prescription

Key Takeaways

  • Writing a prescription involves seven key parts: prescriber’s info, patient’s info, recipe (Rx), signatura (Sig), dispensing instructions, refills, and prescriber’s signature.
  • Ensure that prescriptions are legible and avoid ambiguous abbreviations to minimize errors.
  • For controlled substances, federal law allows limited refills depending on the schedule of the drug.
  • E-prescribing reduces risks associated with illegible handwriting and improves accuracy.

The Seven Parts of a Prescription

Are you learning to write a prescription? It’s not that difficult once you know the seven steps to write a prescription safely. Every drug prescription consists of seven parts: the prescriber’s information, the patient’s information, the recipe (the medication, or Rx), the signatura (the patient instructions or Sig), the dispensing instructions (how much medication to be dispensed to the patient or Disp), the number of refills (or Rf), and the prescriber’s signature (including his or her National Provider Identifier and/or Drug Enforcement Agency number). Below are each of these sections in detail.

Time needed: 3 minutes

Steps for writing a prescription:

  1. Prescriber’s Information

    This information is usually found at the top of the prescription. It generally consists of the prescribing clinician’s name, office address, and contact information (usually the office’s telephone number).

  2. Patient’s Information

    Below the prescriber’s information is the patient’s information. This section will include the patient’s full name, age, and date of birth. Sometimes the patient’s home address will be found here, as well. You should also specify the date you wrote the prescription.

  3. Recipe (Rx)

    The recipe should include the medication being prescribed, its dose, and its dosage form. For example, if you are prescribing 650 milligrams (mg) tablets of acetaminophen, you would write “acetaminophen 650 mg tablets” or “acetaminophen 650 mg tabs.”

  4. Signatura (Sig)

    After the recipe is the signature, the signature (Sig) gives the patient instructions on how to take the medication. The Sig should include information on how much drug to take, how to take it, and how often to take it. For example, if you would like your patient to take one 650 mg tablet of acetaminophen every six hours, you would write “Take 1 tablet by mouth every six hours” or, using abbreviations, “1 tab PO q6h.”

    For as-needed or pro re nata (PRN) prescriptions, you should indicate that the prescription is PRN and describe the conditions under which your patient can take the prescribed medication. Writing your prescription as a PRN order essentially gives the patient the option to take the drug when needed. Let’s say that you would like your patient to be able to take one 650 mg tablet of acetaminophen every six hours when he or she has a headache. In that case, your instructions would read, “Take 1 tablet by mouth every six hours as needed for a headache” or “1 tab PO q6h PRN headache.”

  5. Dispensing Instructions (Disp)

    Next comes the dispensing instructions, which let the pharmacist know how much medication you would like your patient to receive. You should include the amount of medication you would like to be dispensed and the form in which it should be released. You should also make sure to write out any numbers you use here to minimize the risk of a medication error. For our acetaminophen example, if you would like your patient to receive a one-week supply (or 28 tablets) of the medication, you would write “28 (twenty-eight) tablets” or “28 (twenty-eight) tabs.”

  6. Number of Refills (Rf)

    After the dispensing instructions, specify how many times you would like your patient to refill his or her medication. Be sure to write out again any numbers you use. If you do not want to prescribe any refills, write “zero refills.” For our hypothetical acetaminophen example, if you are prescribing one refill, you would write “1 (one) refill.”

  7. Prescriber’s Signature

    At the bottom of the prescription, you should sign your name. Oftentimes, you will include your National Provider Identifier (NPI) in this section. For controlled substances, you usually will include your Drug Enforcement Agency Number. These are necessary for the pharmacy to verify your prescription more easily.

So for our hypothetical acetaminophen example, our prescription looks like this:

Example of a properly written prescription following the 7 steps.
Example of a properly written prescription following the 7 steps.

In 2020, over four and a half billion prescriptions were filled at pharmacies across the United States. Given their sheer prevalence, prescriptions are a key source of medical errors. In fact, prescription errors account for 70% of medication errors that result in harm. Thus, it is crucial that all clinicians master the ability to properly write a prescription.

How to Avoid Common Prescription Errors

In learning to write a prescription properly, it is worth discussing three common sources of prescription errors. First, if you are handwriting your prescription, make sure that it is legible. While e-prescribing is increasingly making handwritten prescriptions a thing of the past, you will likely have to manually prescribe medications at some point in your career. Illegible prescriptions are a source of frustration for patients, pharmacists, and other medical providers, and can increase the risk of medication errors. No matter how busy you are, it is always better to spend a few extra seconds slowly writing out a legible prescription than risk your patient’s health.

Second, be cautious when using abbreviations. While abbreviations are commonly used in medicine, you should keep in mind that the risk of a medication error is increased when abbreviations are ambiguous or misused. So if you choose to use abbreviations in your prescriptions, be sure only to use well-known ones (commonly used medical abbreviations can be found here). If you are unsure whether you should use an abbreviation, spend the extra few seconds to write out your directions completely.

Last, many prescription errors stem from confusing drug names, incorrect dosing units, and misplaced decimals. Medications with similar names or appearances (like Celebrex and Celexa) can be mistaken for one another, leading to serious adverse outcomes. Dosing errors are also common when milligrams, micrograms, or milliequivalents are confused. Decimal placement mistakes, such as adding a trailing zero after a decimal (such as writing “1.0 mg” instead of just “1 mg”) or omitting a leading zero before a decimal (for example: writing .1mg instead of 0.1mg for clarity), can cause confusion, with a medication accidentally being filled at ten times the intended dose!

Careful review of each prescription, clear notation of measurement units, and consistent use of leading zeros help eliminate these frequent and dangerous errors.

Summary of the 7 Steps to Write a Prescription

FAQ

What are the seven parts of a prescription?

Prescriber’s information, patient’s information, recipe (Rx), signatura (Sig), dispensing instructions, refills, and prescriber’s signature.

What are the most common prescription errors?

Illegible handwriting and ambiguous abbreviations are two of the leading causes.

How many refills can be written for controlled substances?

Federal law allows up to five refills within six months for most Schedule III-V drugs. Schedule II drugs cannot be refilled and require a new prescription each time.

What is a PRN prescription?

“PRN” means “as needed.” It allows a patient to take medication only when specific symptoms occur, such as pain or fever, within prescribed limits.

Can medical students or residents write prescriptions?

Only licensed prescribers may sign and issue prescriptions. Residents typically prescribe under a supervising physician’s license and institutional DEA registration.

Are electronic prescriptions safer than handwritten ones?

Yes. E-prescribing reduces errors caused by illegible handwriting and most systems automatically check for drug interactions, allergies, and duplicate therapies.

Should I always add a leading zero before a decimal?

Yes. Always place a zero before a decimal point for doses less than one (for example, write “0.5 mg,” not “.5 mg”). This prevents misreading the dose as “5 mg,” a common and potentially dangerous error.

Should I put a trailing zero after a decimal?

No. Never use a trailing zero after a whole number (for example, write “1 mg,” not “1.0 mg”). The extra zero can be misread as “10 mg,” which may cause a tenfold dosing error.

1 thought on “How to Write a Prescription (with Examples) | 7 Steps for Safety”

  1. Great overview of prescriptions. My significant other is a pharmacist, and he always stresses the importance of CLEAR prescription information from the physician.

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About Kunal Sindhu

Kunal Sindhu, MD, is an assistant professor in the Department of Radiation Oncology at the Icahn School of Medicine at Mount Sinai and New York Proton Center. Dr. Sindhu specializes in treating cancers of the head, neck, and central nervous system.
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