What Ophthalmologic Feature Is This Child Most Likely To Develop?

A 5-year-old male presents to his pediatrician for a yearly check-up and immunizations. On examination, numerous light brown macules are noted on his face, arms, and torso, and freckling is seen under his arms. His mother has several soft cutaneous nodules on her arms. Which of the following ophthalmologic features ... Read more

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Updated February 27, 2019 by Figure 1

Where Is A Chordoma Most Likely To Occur?

A 21-year-old female is referred with a one-year history of neck pain, difficulty swallowing, and numbness of the tongue. Physical, ophthalmologic, and neurological exams are all unremarkable. An MRI later demonstrates the findings seen here ... Read more

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Updated February 27, 2019 by Figure 1

Which additional CSF finding is most likely?

An 11-month-old male with a two-day history of irritability and lethargy is brought to the emergency department by his mother. She reports that he has vomited four times today and has had fewer wet diapers ... Read more

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Updated February 27, 2019 by Figure 1

What’s Causing These Pruritic Lesions?

A 38-year-old man presents with itchy, scaly lesions on his elbows and small, erythematous papules in the web spaces of his fingers. What is the most likely diagnosis? A. Atopic dermatitisB. ScabiesC. PsoriasisD. Tinea corporis ... Read more

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Updated February 27, 2019 by Figure 1

What Changes Would You Expect To See On Repeat X-Ray?

A 60-year-old man presents to the emergency department with worsening shortness of breath and a non-productive cough. He has congestive heart failure and was treated three weeks earlier at a neighboring hospital. On examination, he ... Read more

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Updated February 27, 2019 by Figure 1

Do you recognize this ominous sign?

What underlying condition is most likely? A 62-year-old female presents with fatigue and innumerable pruritic, keratotic lesions on her back and neck which she says developed quite suddenly two months ago. A blood test reveals ... Read more

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Updated February 27, 2019 by Figure 1

Why Are These Gallstones Black? 

A 45-year-old female presents to the emergency department with abdominal pain and vomiting. She mentions the pain radiates to her right shoulder and has been constant for about six hours. She is febrile and the ... Read more

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Updated February 27, 2019 by Figure 1

What’s Causing This Cancer Patient’s Painful Rash?

A 44-year-old female recently diagnosed with acute myeloid leukemia presents with a five-day history of a ​fever, malaise, and a painful rash ​approximately three weeks after chemotherapy​. Examination reveals erythematous papules on her back, arms, ... Read more

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Updated February 4, 2021 by Figure 1

Hot Potato Voice and Stridor—What’s the Cause?

Which medication is the most likely cause of this patient’s reaction? A 75-year-old female presents with acute swelling of the tongue. She is taking anti-hypertensive medication and has no known allergies. During the course of ... Read more

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Updated February 27, 2019 by Figure 1

Which Malignancy Is This Patient At Risk For?

A 62-year-old female presents with a new non-pruritic rash and muscle weakness. She mentions having trouble carrying her young grandchildren recently and getting up from the couch. Examination reveals an erythematous rash on her face, ... Read more

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Updated February 27, 2019 by Figure 1

Do recognize this genetic disorder?

A full-term female infant is born to a healthy 34-year-old woman. Newborn examination reveals a broad chest with widely spaced nipples, a webbed neck, and lymphedema of the feet. Investigations including a karyotype analysis are ... Read more

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Updated February 27, 2019 by Figure 1

Do you recognize these ring-shaped lesions?

A 69-year-old woman with a history of hypertension and irritable bowel syndrome presents with multiple ring-shaped lesions on both hands. The lesions are non-pruritic and developed over the past four days. When she visits for ... Read more

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Updated February 27, 2019 by Figure 1

Why Did These Lesions Appear?

A 58-year-old woman presents two days after a cardiac catheterization with malaise, fatigue, and new violaceous livedoid lesions on her feet. She is also found to have mild acute renal dysfunction. What is the cause ... Read more

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Updated February 27, 2019 by Figure 1

What will exacerbate this patient’s condition?

A 70-year-old male with a history of hypertension presents with a fever and severe pain in both his hands. Examination reveals swollen, erythematous, and tender nodules on the joints of his fingers. Arthrocentesis demonstrates negatively ... Read more

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Updated February 27, 2019 by Figure 1

What’s causing this patient’s spontaneous laughter?

A four-year-old girl is referred to a pediatric neurologist with new-onset generalized tonic-clonic seizures. Her father mentions that she has also had sudden episodes of spontaneous unexplained loud laughter for the past year, and they ... Read more

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Updated February 27, 2019 by Figure 1